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电脑建网站软件,网站建设排名公司, 中国人免费观看,长沙手机模板建站ISRIB#xff08;Integrated Stress Response Inhibitor#xff0c;AbMole#xff0c;M9242#xff09;是一种小分子化合物#xff0c;能够特异性抑制整合应激反应#xff08;ISR#xff09;的激活。ISR是细胞在应激条件下#xff08;如缺氧、病毒感染等#xff09;通…ISRIBIntegrated Stress Response InhibitorAbMoleM9242是一种小分子化合物能够特异性抑制整合应激反应ISR的激活。ISR是细胞在应激条件下如缺氧、病毒感染等通过磷酸化真核翻译起始因子2αeIF2α来调控蛋白质合成的保守通路[1]。磷酸化的eIF2α会抑制鸟苷酸交换因子eIF2B的活性从而减缓蛋白质合成[2]。ISRIB通过结合eIF2B的特定位点逆转eIF2α磷酸化对eIF2B的抑制恢复蛋白质翻译[3]。ISRIBIntegrated Stress Response InhibitorAbMoleM9242通过调控整合应激反应表现出多种生物学效应SRIB能减轻β淀粉样蛋白Amyloid β Protein诱导的神经元死亡但不影响β淀粉样蛋白的生成[4]。在胶质母细胞瘤GB细胞中ISRIB可增强细胞对TemozolomideTMZ 和低氧诱导的凋亡的敏感性[5]。ISRIB在小鼠模型中能改善慢性应激CRS诱导的抑郁样行为表现为蔗糖偏好增加和强迫游泳试验FST中不动时间减少[6]。此外ISRIB可减轻脑损伤后的认知功能衰退并增强健康小鼠的认知能力[7]。ISRIB在结核分枝杆菌感染的小鼠模型中通过抑制PKR介导的eIF2α磷酸化阻断了肺肉芽肿坏死的发生[8]。这些发现表明ISRIB可作为调控蛋白质稳态的工具分子为理解ISR在肿瘤、免疫和神经功能中的作用提供了帮助。AbMole为全球科研客户提供高纯度、高生物活性的抑制剂、细胞因子、人源单抗、天然产物、荧光染料、多肽、化合物库、抗生素等科研试剂全球大量文献专利引用。AbMole是ChemBridge中国区官方指定合作伙伴。*本文所述试剂仅供科研使用参考文献及鸣谢[1] He, W.; Patil, A. S.; Xu, Y. Development and validation of a UHPLC-MS/MS method for the quantitative analysis of trans-ISRIB in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences2025, 1252, 124469.[2] Zyryanova, A. F.; Weis, F.; Faille, A.; et al. Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science (New York, N.Y.)2018, 359 (6383), 1533-1536.[3] Zyryanova, A. F.; Kashiwagi, K.; Rato, C.; et al. ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Molecular cell2021, 81 (1), 88-103.e106.[4] Hosoi, T.; Kakimoto, M.; Tanaka, K.; et al. Unique pharmacological property of ISRIB in inhibition of Abeta-induced neuronal cell death. Journal of pharmacological sciences2016, 131 (4), 292-295.[5] Lorenz, N. I.; Sittig, A. C. M.; Urban, H.; et al. Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide. Scientific reports2021, 11 (1), 14161.[6] Luhong, L.; Zhou, H. M.; Tang, X. H.; et al. PERK inhibitor (ISRIB) improves depression-like behavior by inhibitions of HPA-axis over-activation in mice exposed to chronic restraint stress. Behavioural brain research2024, 471, 115122.[7] Anand, A. A.; Walter, P. Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response. The FEBS journal2020, 287 (2), 239-245.[8] Bhattacharya, B.; Xiao, S.; Chatterjee, S.; et al. The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas. The Journal of clinical investigation2021, 131 (3).