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建网站找那家好,泉州网站优化排名推广,wordpress 小程序主题,塘厦网站建设Berberine#xff08;BBR, 小檗碱#xff0c;AbMole#xff0c;M9168#xff09;是一种异喹啉类生物碱#xff0c;广泛存在于黄连等植物中#xff0c;具有多靶点作用机制和广泛的科研应用价值#xff0c;近年来备受关注。在细胞模型中#xff0c;研究显示Berberine可通…BerberineBBR, 小檗碱AbMoleM9168是一种异喹啉类生物碱广泛存在于黄连等植物中具有多靶点作用机制和广泛的科研应用价值近年来备受关注。在细胞模型中研究显示Berberine可通过调控多种信号通路发挥效应。例如Berberine小檗碱在肝癌细胞HepG2中以剂量和时间依赖性方式抑制Cyclin D1表达并通过促进其磷酸化加速降解[1]。在卵巢癌细胞SKOV3和3AO中BerberineBBRCAS No.2086-83-1通过抑制c-Myc下调SLC1A5的表达从而抑制谷氨酰胺摄取干扰肿瘤细胞的氨基酸代谢[2]。并且Berberine在弥漫大B细胞淋巴瘤DLBCL模型中通过抑制c-Myc的转录降低了CD47表达增强巨噬细胞的吞噬作用[3]。Berberine小檗碱在动物实验中也有着广泛的应用。在类风湿关节炎研究中Berberine聚合物胶束通过AMPK通路显著提升了抗炎效果其效能较游离分子提高了约10倍[4]。Berberine在Balb/c裸鼠异种移植肿瘤模型中通过调节脂代谢抑制肿瘤生长[5]。Berberine在糖尿病动脉粥样硬化的研究中通过激活KLF16-PPARα轴改善脂糖代谢紊乱并减少血管炎症从而稳定动脉斑块[6]。Berberine在小鼠胰岛素抵抗模型中可逆转高果糖饮食诱导的大鼠体重增加、血脂异常和胰岛素耐受同时提升L6骨骼肌细胞的葡萄糖摄取能力[7]。范例详解Chem Biol Drug Des. 2025 Apr;105(4):e70111.上海复旦大学、南京中医药大学的科研人员在上述文章中使用了AbMole的Berberine小檗碱BBR, AbMoleM9168以探究Berberine对小鼠肺纤维化模型的抑制效果。实验人员利用博来霉素BleomycinBLM构建了小鼠纤维化模型结果显示博来霉素诱导的小鼠肺组织中存在THBS2表达上调的现象该蛋白主要参与组织修复和血管生成。而Berberine在小鼠体内缓解了博来霉素诱导的肺部纤维化。科研人员发现BBR通过使THBS2/Smad2/3通路失活抑制了博来霉素诱导的纤维化这为Berberine的应用提供了理论基础。Berberine通过抑制THBS2表达减弱了纤维生成反应参考文献及鸣谢[1] Wang, N.; Wang, X.; Tan, H. Y.; et al. Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells. International journal of molecular sciences2016, 17 (11).[2] Li, J.; Zou, Y.; Pei, M.; et al. Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells. Journal of Cancer2021, 12 (1), 207-216.[3] Ren, S.; Cai, Y.; Hu, S.; et al. Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis. Biochemical pharmacology2021, 188, 114576.[4] Fan, X. X.; Xu, M. Z.; Leung, E. L.; et al. ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria. Nano-micro letters2020, 12 (1), 76.[5] Li, L.; Peng, Z.; Hu, Q.; et al. Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs. Evidence-based complementary and alternative medicine : eCAM2020, 2020, 6195050.[6] Man, B.; Hu, C.; Yang, G.; et al. Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARalpha in ApoE(-/-) mice. Biochemical and biophysical research communications2022, 624, 59-67.[7] Cheng, J.; Ma, X.; Yan, G.; et al. High fructose-induced skeletal muscle insulin resistance could be alleviated by berberine via AMPD1 and ADSL. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association2023, 175, 113731.